Neurovirulence of murine coronavirus JHM temperature-sensitive mutants in rats.
Identifieur interne : 001E14 ( Main/Exploration ); précédent : 001E13; suivant : 001E15Neurovirulence of murine coronavirus JHM temperature-sensitive mutants in rats.
Auteurs : H. Wege ; M. Koga ; R. Watanabe ; K. Nagashima ; V. Ter MeulenSource :
- Infection and Immunity [ 0019-9567 ] ; 1983.
Abstract
The murine coronavirus strain JHM is highly neurotropic in rats and has a marked tendency to cause demyelinating central nervous system diseases after intracerebral inoculation. The clinical diseases observed range from an acute encephalomyelitis occurring within 2 weeks postinfection to a subacute demyelinating encephalomyelitis developing several weeks or months postinfection. Uncloned wild-type virus induced both acute and subacute diseases, whereas cloned JHM virus grown in tissue culture caused only acute disease without the pronounced lesions of primary demyelination. In contrast, temperature-sensitive mutants selected from that clone were capable of inducing subacute demyelinating encephalomyelitis after prolonged incubation times. Viruses recovered from diseased animals were still temperature sensitive. Inoculation of temperature-sensitive mutants into suckling rats (age, 10 to 15 days) produced high rates of subacute demyelinating diseases running a more chronic course; these diseases often were not fatal. Those rats which did not show clinical signs frequently revealed inflammatory demyelinating lesions. These findings indicate that the rate and type of clinical disease are dependent on the neurovirulence of the virus mutant used for inoculation and the age of the animals at the time of infection.
Url:
PubMed: 6301992
PubMed Central: 348101
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000455
- to stream Pmc, to step Curation: 000455
- to stream Pmc, to step Checkpoint: 000B01
- to stream Ncbi, to step Merge: 001644
- to stream Ncbi, to step Curation: 001644
- to stream Ncbi, to step Checkpoint: 001644
- to stream Main, to step Merge: 001E40
- to stream Main, to step Curation: 001E14
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurovirulence of murine coronavirus JHM temperature-sensitive mutants in rats.</title>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name>
</author>
<author><name sortKey="Koga, M" sort="Koga, M" uniqKey="Koga M" first="M" last="Koga">M. Koga</name>
</author>
<author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name>
</author>
<author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K" last="Nagashima">K. Nagashima</name>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">6301992</idno>
<idno type="pmc">348101</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC348101</idno>
<idno type="RBID">PMC:348101</idno>
<date when="1983">1983</date>
<idno type="wicri:Area/Pmc/Corpus">000455</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000455</idno>
<idno type="wicri:Area/Pmc/Curation">000455</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000455</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B01</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B01</idno>
<idno type="wicri:Area/Ncbi/Merge">001644</idno>
<idno type="wicri:Area/Ncbi/Curation">001644</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001644</idno>
<idno type="wicri:doubleKey">0019-9567:1983:Wege H:neurovirulence:of:murine</idno>
<idno type="wicri:Area/Main/Merge">001E40</idno>
<idno type="wicri:Area/Main/Curation">001E14</idno>
<idno type="wicri:Area/Main/Exploration">001E14</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neurovirulence of murine coronavirus JHM temperature-sensitive mutants in rats.</title>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name>
</author>
<author><name sortKey="Koga, M" sort="Koga, M" uniqKey="Koga M" first="M" last="Koga">M. Koga</name>
</author>
<author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name>
</author>
<author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K" last="Nagashima">K. Nagashima</name>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name>
</author>
</analytic>
<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="1983">1983</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The murine coronavirus strain JHM is highly neurotropic in rats and has a marked tendency to cause demyelinating central nervous system diseases after intracerebral inoculation. The clinical diseases observed range from an acute encephalomyelitis occurring within 2 weeks postinfection to a subacute demyelinating encephalomyelitis developing several weeks or months postinfection. Uncloned wild-type virus induced both acute and subacute diseases, whereas cloned JHM virus grown in tissue culture caused only acute disease without the pronounced lesions of primary demyelination. In contrast, temperature-sensitive mutants selected from that clone were capable of inducing subacute demyelinating encephalomyelitis after prolonged incubation times. Viruses recovered from diseased animals were still temperature sensitive. Inoculation of temperature-sensitive mutants into suckling rats (age, 10 to 15 days) produced high rates of subacute demyelinating diseases running a more chronic course; these diseases often were not fatal. Those rats which did not show clinical signs frequently revealed inflammatory demyelinating lesions. These findings indicate that the rate and type of clinical disease are dependent on the neurovirulence of the virus mutant used for inoculation and the age of the animals at the time of infection.</p>
<sec sec-type="scanned-figures"><title>Images</title>
<fig id="F1"><graphic xlink:href="iai00144-0323-a" xlink:role="1319"></graphic>
</fig>
<fig id="F2"><graphic xlink:href="iai00144-0326-a" xlink:role="1322"></graphic>
</fig>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Koga, M" sort="Koga, M" uniqKey="Koga M" first="M" last="Koga">M. Koga</name>
<name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K" last="Nagashima">K. Nagashima</name>
<name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name>
<name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R" last="Watanabe">R. Watanabe</name>
<name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:348101 |texte= Neurovirulence of murine coronavirus JHM temperature-sensitive mutants in rats. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:6301992" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidV2
This area was generated with Dilib version V0.6.33. |